ZOONOSES A CHALLENGE DANGER.
ZOONOSES A CHALLENGE DANGER BIODIVERSITY, A MENACE FOR HUMAN HEALTH? In nature, animals sting, bite or carry microbes that they can transmit. Plants and fungi cause allergies, poisoning. Although there may be disadvantages associated with different species, the current collapse of biodiversity can cause much greater harm to human health. File Commented by François Mukandila and Jérôme Batungassana. Sources: WHO AFRO: Animal-borne diseases, Inserm Magazine No. 49, April 2021
Of course, animals are peers, companions, friends, subjects of wonder, but also incredible transmitters of infectious diseases or zoonoses, and the sometimes major impact on our societies. In the meantime, the Covid-19's Pandemic Warfare, which no longer ends, is being taken into account. Evidence of global health systems. The three-quarters of new diseases affecting humans are zoonoses. These animal-borne diseases would cause more than 2 billion infections each year. Zoonoses are transmissible infections between green and human animals and vice versa. Causated by pathogens of animal origin, they do not have treatment; That day. Vaccination-avoidable, however, is a concern for their expansion. Improved communication is the best way to prevent and control zoonotic diseases. By definition, a zoonose is an infectious disease that passes through the animal. the man. Pathogenic, viral or parasitic agents may involve unconventional agents and spread; human beings by direct contact or by food, water or the environment. According to the World Health Organization; (WHO), a zoonose (Greek zoon, animal laquo; and noso, laquo; disease) signs a naturally transmissible disease or infection of green animals Human. & laquo; Some infections may have a zoonotic origin and become more specific human diseases. This is potentially the case with the most common form of malaria caused by the parasite Plasmodium falciparum. ORIGIN The first sufficiently documented zoonotic pandemic is the Black Plague of 1347, due to abrasion. the Yersinia vaccine, which would have occurred; One third of Europe's population in five years, 44 million people. However, zoonoses may have begun; à become a à threat from time to time; our program has changed his interactions with other animals, through domestication of the latter, led by Yannick Simonin, a French virologist. The animals are companions or subjects of wonderfully wonderfully, but also incredible transmitters of infectious diseases, or zoonoses, the sometimes major impact on our societies. Trigger factors include: the intensification and globalization of trade, goods, animals and people, which facilitate the introduction and dissemination of disease. Intensive urbanization, which is accompanied by the proliferation of animals that can promote zoonoses in cities. Finally, conflicts, which are responsible for population movements and the weakening of health systems in the countries concerned, are not a problem. No action taken. Closer in time, Dr. Peter Daszak, President of the EcoHealth Alliance and President of the IPBES Workshop said: There are no large aggregates of data. the cause of the Pandemic VOCID-19, or any other modern Pandemic. Human activities, which are The causes of climate change and the loss of biodiversity, also result in a risk of pandemic effects on our environment. Changes in the manner in which we use land, expansion and intensification of agriculture, as well as unsustainable trade, production and consumption, disrupt nature and increase contact between wildlife, livestock, disease and humans. This is the way to the Pandemics. _Raquo; Indeed, in the last ten years alone, we have been able to assist; à Six successive emergencies: Ebola in West Africa, 2013 2016, Zika in Latin America From 2015, Chikungunya in South America between 2013 and 2014, another Ebola in Democratic Republic of Congo in 2018-2020. Cases of plague Madagascar has been reported since 1990 until recently in 2017, and Covid-19 in 2019. Covid, identified in the coronavirus family, is primarily circulating in bats, and zoonotic transfer is causing epidemic diseases in humans. It is therefore crucial to understand how this virus has passed; and has become highly transmissible to humans; Man. Another epidemic, the Monkey Pox, has been identified. Declaration in the DRC the end of 2022. This country reports 95% of known human cases. SITUATION ACCENTED BY OUR MODERN ACTIVITIES As a result, the stress of various pressures on the environment. & laquo; The extension of associated agricultural land forestation increases the risk of contact between wildlife, domestic animals and humans. Intensification of industrial animals increases the risk of animal disease spread. The trafficking and sale of wild animals could increase human exposure to pathogeneic disease. Finally, climate warming is associated with climate change. gas emissions the greenhouse effect could affect the prevalence of wildlife and vector insects, such as mosquitoes. THE WHO ALTERNATIVE AREAS IN AFRICA According to the WHO, the number of zoonotic diseases has increased; 63% in Africa during the 2012-2022 decade compared to the previous year. 2001-2011. The analysis is based on the differences between the 2001 and 2022, 1843 health events. public opinion recorded in the continent. 30% of these events were zoonoses. If these numbers have increased; During the last two decades, a particular peak was recorded. record; in 2019 and 2020, when zoonotic pathogens were re-empowered; approximately 50% of health care events; public. à disease Ebola virus and other viral liver disease account for 70% of these diseases, including dengue, coal, plague, monkeypox, and one of the remaining 30% of other diseases. The most important geographical areas Risks are the regions of Central and Eastern Africa on the African continent, which are the richest in zoonotic mammals and areas rich in primates, such as Equatorial Africa, in the Congo Basin and in West Africa in the tropical forest regions. However, the rest of the African regions are not included. the shelter due to a few factors. These include increased road, rail, maritime and air links between states and with them the animal-human contact fronts. & laquo; With improved transportation in Africa, the threat of pathological zoonotic agents moving to major urban centres is increasing, stated; Matshidiso Moeti, former Regional Director of WHO for Africa during a conference in July 2022. There is also an increase in the population, which, according to Rodolphe Gozlan, is leading to the development of research and development. The Research Institute for Development (IRD): increase in food requirements à trend Suitable for use through intensive rearing, on huge surfaces, with samples with very severe genetic profiles, bioincubators perfect for zoonoses. THE PUBLIC R&EACute OF THE CONGO IN QUESTION ? In Congo's Democratic Republic, zoonoses are a major health problem. This is due to the wealth of biodiversity in the country, the culture and traditions of wild animals, the weakness of surveillance and response systems, and armed conflicts and humanitarian crises affecting the country. Among the zoonoses present in the DRC, the disease is referred to as: Ebola virus, which caused Since 1976, and between 2018 and 2020. Canine rabies, like this, is endacute throughout the country and kills about 1,500 people a year. The yellow fever caused; A half in 2016. African human trypanosomiasis or sleep disease, transmitted by the fly or leptospirosis, which is linked to flooding. Due to gravity and capacity; à The Department of Health is responsible for: a list; six groups of priority zoonoses in the DRC that are: rage, liver disease, and other diseases Ebola and Rift's Stroke, Arbovirosis including yellow fever, Salmonella, Monkeypox (Apespox) and Influenza, including avian influenza and VOCID 19. These diseases, although some have common characteristics, present some differences and involve diversity; of actors. FIGHT AND PREVENTION Of the very well-informed, able to communicate, observe and apply appropriate measures to ensure that no one dies or loses his or her life. cause of the six groups of priority zoonoses à the horizon 2063. The best way to combat the epidemic and the accompanying information resources remains better communication, from prevention to prevention. Resilience. It is well said that the DRC is a country rich in biodiversity, so it is clear that the Community is a country that is rich in biodiversity. information and information for changing the behaviour of live or dead animals. Zoonoses are diseases & agrove; vaccine prevention. The vaccine is the effective means of combating transmission chaicirc or inhibiting the risk of contamination by animals or humans. In the DRC, in its post-covid era, vaccination against covid-19 has been achieved. included in the immunization schedule of pregnant women. People with chronic diseases are also concerned. Since 2022 the country has had a national plan to combat rabies with the support of FAO. The Department of Fisheries and Livestock is looking at an extensive dog vaccination campaign. And thanks to partners such as USAID via Breakthrough Action, the country under the committee; In addition, the Department of Health and Social Services is working to improve the capacity of the media and social leaders to ensure effective communication on zoonoses. DFO VIRUS: WHAT THIS EPIDEMAY SHOULD BE SAID ACKNOWLEDGEMENT IN AFRICA While the World Health Organization acute; 14th August 2024 its highest level of global alert against the threat; The spread of the Mpox, also known as the monkey smallpox, has been taking stock of this known disease since the 1970s, and of its epidemic that has become increasingly common in Africa. What is Mpox? Originally known as Monkey pox, monkey smallpox, and renamed; in 2022 MPox by WHO is a smallpox species. Paradoxically, the Mpox has little to do with it. see with the monkeys, if this is only the case. Isolated; for the first time on primates in a laboratory in Denmark in 1958. In short, although it is still called a monkey-specific disease, it is not via monkeys that this disease is transmitted; human, but gravia; From rodents. WHO has been privileged since the end of 2022 to appoint a member of the World Health Organization. There are two main types of the Mpox virus: Clade 1, present in the Congo Basin in Central Africa; And the 2nd call in West Africa. The virus currently circulating in Europe comes from clade 2, which involves: in the Epidemiary of Nig-Eacute. Mpox is a zoonosis, an infectious disease that passes through the animal. The first human case has been reported. report; in 1970, it was a nine-year-old child who had been able to care for the disease before he died shortly after he had contracted. mumps. Why the Epidemiary has access to the disease? During many years, small, localized epidemiologic outbreaks have been regularly occurring in Central Africa and the United States. West, some countries such as the DRC, Nigeria, Liberia or Cameroon, where the virus is endemic. But it was in 2022 that the WHO declared the epidemic as a global health emergency after more than 75 non-smoking countries, including the United States, Australia, Canada and much of Europe, reported cases. The spread of MPox is rapidly calming in Western countries, but it has taken another turn in recent months in Africa. the two known strains of the virus (clade 1 and clade 2) continued; Traffic, which grew WHO/Agrave; to trigger its highest level of alert. C&rsquo is a disease that has developed which is no longer only transmissible to animals; Dr. Jean Kaseya, Director General of the African Centers for Disease Control and Prevention (Africa CDC), explains: The Democratic Republic of the Congo, which currently accounts for 96% of Mpox's reporting cases, is facing the same situation. a much more virulent strain called 1b, more transmissible and more lethal than the 2nbsp call that was involved in the 2022 epidemic in many Western countries. The virus mutated; and is now passed on to humans. Dr. Kaseya is a human being, with his knowledge and contact, with objects used by an infectious person such as clothes, bed, a chair and a chair. Studies are being conducted as we also suspect transmissions via the airway, and this is the case. Sugrave and Pakistan announced that: have discovered their first cases of Mpox from Variant 1b, as observed; for the first time outside Africa. This variant spreads very rapidly and spreads rapidly. countries in Africa that had never seen it before, such as Rwanda, Kenya and Burundi. We see many cases in Burundi and Uganda, and they are countries that have a lot of contact with the rest of the world. It is therefore a threat to the rest of the world. World Health Organization spokesperson Margaret Harris. - What? Other import cases are likely to be registered in the European region in the coming days and weeks, warned the United Nations organization. À How dangerous is the Mpox? Less virulent than the smallpox of which it is a variant, the danger of Mpox has for a long time been severe; Limited, but the emergence of a new change in the trend is now changing. Before Mpox did not really kill, Dr. Kaseya explains, but today with the new strains, clade 1 can reach a rate of disease; up to and including 10%, which is the norm. Clade 2 is much less dangerous with a rate of toxicity; estimates; around 0.1% is a à Two deaths for 1,000 patients. It was this strain that was abrasive. the origin of the 2022 epidemic, which had resulted in 140 deaths for just over 90,000 cases. The epidemiology of subtype 1b subtype Mpox currently occurring in Africa, and any particularity in the DRC, is, on the other hand, much more dangerous with a rate of success; which averages 3 & agrave; 4%. A total of 38,465 cases of Mpox occurred. in 16 African countries since January 2022, for a total of 456 cases, including a 160% increase in the number of cases in 2024 compared to the previous year. the previous year, according to data published by the Health Agency in 2024; African Union, Africa CDC. Dr. Kaseya stated that there is a risk that, in the DRC alone, those under 15 years of age are more than 60% of the cases. What are the symptoms and how do we protect ourselves? After a six-day period up to and including three weeks of incubation, the first symptoms are of general order and look similar; Illnesses such as fever, muscle aches, disease, fatigue... Then there are the cuten-eacutes that can sometimes be painful and leave scars, but with the emergence of new strains, there are now also cases of ougrave; The raw material appears before the general symptoms, Dr. Jean Kaseya said. The policy operates in two general ways: four weeks, but to protect yourself from the virus that is not known for curative treatment, the most effective is to keep a good body health and wash your hands thoroughly. Individuals with multiple sexual partners must also be particularly vigilant because they are aware of the need to: the virus is transmitted via close contacts. The vaccine, the only treatment to control the epidemic Developmental vaccines to immunize against smallpox are also effective. 80% against the Mpox, which could allow to come quite quickly à the end of the epidemic. However, since WHO announced the disease eradication in 1980, vaccination campaigns have been conducted. Stoppage, which could also partly explain this increase in Mpox. The vaccine against smallpox that was protected by growing action against smallpox kept it for a long time, but individuals who have not been vaccinated since the time of the smallpox vaccination have not been vaccinated; vaccine, which makes a larger number of servers of people likely to contract monkey smallpox, was explained in 2022 on the RFI ?39; Institut Pasteur, Arnaud Fontanet. increasing circulation By setting its highest level of alert, Emergency health care; International Port Authority In 2024, the WHO was able to give priority; à the fight against the MPox virus, while its budget is heavily framed. $1.5 million was spent on research. What is it? WHO's emergency fund. The organization finds that its response plan does not require at least $15 million in initial funding. The WHO announcement will also provide funding for vaccine access in Africa. If vaccines against Mpox exist, they are still too small, especially on the African continent. Health Agency African Union Africa CDC announced; Approximately 200nbsp were used in Africa. Support from the European Union (EU) with Danish manufacturer Bavarian Nordic in capacity; to produce two million additional doses by the end of 2024 and up to and including 2024; ten million by the end of 2025. A situation that further supports the urgency of the situation. Africa to become a vaccine dependent. We are told that there is currently a stock of 200,000 doses of vaccines; the world, while a country like the DRC is on the rise. Dr. Jean Kaseya was awarded three million francs. Getting Started producing our own vaccines and medicines, it is for me the fight of the race, concludes the Director of Africa CDC. RDC FRAMEWORK: ENVIRONMENT 3,000 CASES SUSPECTS OF MONKEYPOX EN 2022 More than 61 000 cases at the end of 2024 1,134 cases of Monkeypox (monkey parole) were reported. registered since early 2024 in the DRC, declared the Director of the National Program for the Control of this Disease at a Research and Development Union on Support; the national response to the outbreak of cholera and Monkeypox. Dr. Dieudonn? Mwamba, Director General of the National Institute of Health; public, has been given the differences in this response, know an increase in case notification, about 3,000 suspect cases in 2022; more than 61,000 cases at the end of 2024; biological detection is improved from 9% in 2022; While considerable effort is still needed to make the decision on the diagnostic approach, the decline in health status is 4.5% in 2022. 2.2% at the end of 2024. Dr. Robert Shungu, Director of the Monkeypox Program, indicated that the provinces most affected were Lower Uele, Ecuador, Greater Kasaï, Kinshasa, Maï-Ndombe, Maniema, Mongala, North Ubangi, Sankuru, South Kivu, South Ubangi, Tshopo and Tshuapa. Dr. Shungu also noted that children under 15 years of age are more affected by this disease and account for 68% of suspected cases. & laquo; Young males are more affected than girls because today, the infection of this disease is more sexual, continued this doctor. He pointed out that the problems of the These include the centralization of analysis centres, delays in biological detection, stock failure of material and active majority samples; health areas; and the difficulties in transporting samples from rural areas to the capital; Kinshasa. In terms of perspectives, Director Shungu has emphasized that the program includes, among other things, updating the Monkeypox Response and Response Plan and improving monitoring. One Health. BOX L’ IMPLICATION OF THE CHEESE OF THE CONGOLAIS IN THE RIPOSTE AGAINST DFO President Tshisekedi took place on Saturday, January 04, 2025. The National Institute for Biomedical Research (INRB), the official handover ceremony for the response to the epidemic in the DRC. This is an important donation from Africa CDC, which adds to the new vehicles and other means used. the disposition of the Mpox response by the Congolese government. Dr. Roger Kamba, Minister of Health, Health and Social Affairs of the DRC, thanked Dr. the President of the Republic for his or her presence in the country the event and its personal involvement. This gift will enable à our health care populations; quality, regardless of their living conditions, demonstrate that access to basic services is a priority; for you, he said; in his speech. And to conclude: We are aware that today's donation will allow us to diagnose and treat more quickly. Speaking & Agrave; His turn, Dr. Jean Kaseya, Director General of Africa CDC, thanked him; the Head of the Congolese State for his involvement in the response to the Mpox. He recalled; & laquo; that, in August 2024, President Tshisekedi had been required to pay; US$10 million to combat this epidemic. Dr. Kaseya also referred to the problem of testing the MPox in the DRC: At present, only the cities of Kinshasa and Goma are covered, and with this donation seven other provinces will be added, he said. Definition à assist the Congolese government à DDC announced that it would increase its ability to fight the problem. : We have decided to We are doing everything we can to support and use our strong voice to call partners. come with the Congolese government.
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